Good, quick video on scientifically sound weight-loss tips:
streamified.me/l/14ausa7t
Monday, August 27, 2012
Friday, June 01, 2012
This is a potential Game Changer:
http://www.medscape.com/viewarticle/764745?src=mpnews&spon=34
Curing Diabetes Via Surgery, Without Weight Loss
"Curiously, although patients shed pounds, there was no correlation between weight loss and blood glucose. "Bariatric surgery is more effective on diabetes than obesity," said Dr. Rubino. "Patients don't become lean, but they do not have diabetes anymore."
Research from the University of Toronto, reported online this month in Nature Medicine, may finally explain why. It examined the effects of bypass surgery on rats with type-1 diabetes, which is considered even harder to treat than type-2.
Normally the jejunum receives only digested mush, as nutrients have already been absorbed in the duodenum, explained lead researcher Tony Lam. Bypassing the duodenum allows the jejunum to receive an influx of nutrients for the first time, said Lam. Sensing them, the jejunum sends a "got glucose!" signal to the brain. The brain interprets that as a sign of glucose overabundance and orders the liver to decrease glucose production. Result: The rats no longer have diabetes.
"I believe that similar mechanisms are taking place in surgery for type-2 diabetes," said Lam. "It strengthens the case for the surgery treating diabetes independent of weight loss."
His rat study shows why lap banding and stomach stapling are less effective against diabetes than gastric bypass. Banding causes diabetes to go into remission in about 50% of patients, probably due to weight loss, said endocrinologist Dr. Allison Goldfine of the Joslin Diabetes Center in Boston.
In contrast, the diabetes-remission rate after Roux-en-Y is 80% to 85%. "The improvements in blood glucose with Roux-en-Y appear to occur very early, by day three after surgery, so patients are being discharged with no medication," she said. Something other than weight loss "must be going on."
http://www.medscape.com/viewarticle/764745?src=mpnews&spon=34
Curing Diabetes Via Surgery, Without Weight Loss
"Curiously, although patients shed pounds, there was no correlation between weight loss and blood glucose. "Bariatric surgery is more effective on diabetes than obesity," said Dr. Rubino. "Patients don't become lean, but they do not have diabetes anymore."
Research from the University of Toronto, reported online this month in Nature Medicine, may finally explain why. It examined the effects of bypass surgery on rats with type-1 diabetes, which is considered even harder to treat than type-2.
Normally the jejunum receives only digested mush, as nutrients have already been absorbed in the duodenum, explained lead researcher Tony Lam. Bypassing the duodenum allows the jejunum to receive an influx of nutrients for the first time, said Lam. Sensing them, the jejunum sends a "got glucose!" signal to the brain. The brain interprets that as a sign of glucose overabundance and orders the liver to decrease glucose production. Result: The rats no longer have diabetes.
"I believe that similar mechanisms are taking place in surgery for type-2 diabetes," said Lam. "It strengthens the case for the surgery treating diabetes independent of weight loss."
His rat study shows why lap banding and stomach stapling are less effective against diabetes than gastric bypass. Banding causes diabetes to go into remission in about 50% of patients, probably due to weight loss, said endocrinologist Dr. Allison Goldfine of the Joslin Diabetes Center in Boston.
In contrast, the diabetes-remission rate after Roux-en-Y is 80% to 85%. "The improvements in blood glucose with Roux-en-Y appear to occur very early, by day three after surgery, so patients are being discharged with no medication," she said. Something other than weight loss "must be going on."
Thursday, April 26, 2012
Best 2nd Line Therapy for Diabetes treatment identified
It has always bugged me that while we know metformin is the best 1st line treatment for Type 2 Diabetes, there has been no clear consensus on what to add to metformin if the patient does not reach the A1c goal of <7%.
Medscape.org had a nice article/CME activity showing GLP-1 treaments (Byetta, Victoza, Bydureon) should be preferred.
http://www.medscape.org/viewarticle/762095 :
Medscape.org had a nice article/CME activity showing GLP-1 treaments (Byetta, Victoza, Bydureon) should be preferred.
http://www.medscape.org/viewarticle/762095 :
- "A previous study by Dodd and colleagues found that most type 2 diabetes was managed with oral medications, and slightly more than half of patients had achieved good glycemic control. There was a shift in the most popular oral medications from sulfonylureas to thiazolidinediones during the study period from 1999 to 2004.
- GLP-1 analogues are recommended as second-line treatment of type 2 diabetes in the current study by Liu and colleagues based on their efficacy in reducing both A1C levels and body weight while presenting a low risk for hypoglycemia. "
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